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目的：为观察了解谷氨酸（Ｇｌｕ）和γ－氨基丁酸（ＧＡＢＡ）在发生脑缺血－再灌注损伤时的变化规律。方法：采用Ｌｏｎｇａ＇ｓ方法建立鼠大脑中动脉脑缺血－再灌注模型，观察了正常对照组，单纯缺血２小时，单纯缺血３小时，缺血２小时－再灌注１小时，缺血３小时－再灌注１小时，Ｇｌｕ和ＧＡＢＡ的变化及二者之间的关系。结果：发生再灌注损伤时，Ｇｌｕ和ＧＡＢＡ的比例与正常对照组有显著差异（Ｐ＜０．０１）。结论：在缺血－再灌注损伤发生过程中，脑组织内不仅是Ｇｌｕ和ＧＡＢＡ含量发生变化，而且二者比例严重失调，以上两个方面在脑缺血－再灌注损伤中可能起一定作用。
Objective: To observe the changes of glutamate (Glu) and γ-aminobutyric acid (GABA) during cerebral ischemia-reperfusion injury. Methods: The model of middle cerebral artery occlusion (MCAO) in rats was established by Longa ’s method. The normal control group was given ischemia for 2 hours, ischemia for 3 hours, ischemia for 2 hours - reperfusion for 1 hour, ischemia 3 hours - reperfusion 1 hour, Glu and GABA changes and the relationship between the two. Results: The ratio of Glu and GABA in reperfusion injury was significantly different from that in normal control group (P <0.01). CONCLUSION: During the process of ischemia-reperfusion injury, the contents of Glu and GABA in brain tissue are not only changed, but also the ratio of them is severely imbalanced. These two aspects may play a role in cerebral ischemia-reperfusion injury.