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全反式维甲酸(维生素 A 酸)治疗急性早幼粒细胞白血病(APL)临床完全缓解率很高,与常规细胞毒性化疗剂不同,全反式维甲酸具有使恶性细胞转化为成熟髓样细胞的生物学作用。大多数病人均能耐受治疗。但是,作者在应用全反式维甲酸治疗APL 的过程中,发现某些病人可出现一种临床综合征,其特征为发热、呼吸困难、体重增加、胸腔或心包积液及低血压等。本文报告了这种并发症的临床、尸检所见及其该并发症的处理方案。
All-trans retinoic acid (vitamin A) is highly clinically effective in the treatment of acute promyelocytic leukemia (APL). Unlike conventional cytotoxic chemotherapeutics, all-trans retinoic acid has the ability to transform malignant cells into mature myeloid cells. The biological effects. Most patients can tolerate treatment. However, in the course of the application of all-trans retinoic acid in the treatment of APL, the authors found that some patients may develop a clinical syndrome characterized by fever, dyspnea, weight gain, pleural or pericardial effusion, and hypotension. This article reports on the clinical, autopsy findings, and treatment options for this complication.