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采用免疫组化 SABC法对 81例膀胱移行细胞癌患者癌组织中细胞粘附分子 CD4 4V6和 CD4 4S的表达进行检测。结果显示 ,CD4 4V6的阳性表达与膀胱癌临床分期、病理分级有显著关系 ( P均 <0 .0 5) ,伴淋巴结转移组的 CD4 4V6阳性表达率显著低于未转移组 ( P<0 .0 1)。 CD4 4S的阳性表达与临床分期、病理分级无明显相关性 ,但与淋巴结转移有显著关系 ( P<0 .0 1)。认为 CD4 4V6和 CD4 4S均与膀胱癌转移明显相关 ,可作为监测膀胱癌转移的可靠指标。
Immunohistochemical SABC method 81 cases of transitional cell carcinoma of the bladder cancer cell adhesion molecule CD4 4V6 and CD4 4S expression was detected. The results showed that the positive expression of CD4 4V6 was significantly associated with the clinical stage and pathological grade of bladder cancer (all P <0.05). The positive rate of CD4 4V6 in lymph node metastasis was significantly lower than that in non-metastatic group (P <0. 0 1). There was no significant correlation between the positive expression of CD4 (superscript +) 4S and the clinical stage and pathological grade, but there was a significant correlation between the expression of CD4 (superscript +) S and lymph node metastasis (P <0.01). It is considered that both CD4 4V6 and CD4 4S are significantly associated with the metastasis of bladder cancer and can be used as a reliable indicator to monitor the metastasis of bladder cancer.