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目的观察非洛地平联合厄贝沙坦治疗老年性高血压的临床疗效。方法笔者所在医院2009年5月～2011年5月收治老年性原发性高血压56例,口服非洛地平缓释片5mg/d,联合厄贝沙坦150mg/d,晨起一次顿服治疗,疗程为8周。观察用药期间血压、心率及不良反应情况。结果经过治疗,患者第4周收缩压(SBP)、舒张压(DBP)、平均动脉压(MAP)均显著降低,较治疗前差异有统计学意义(P<0.05)。此后随着疗程延长,收缩压、舒张压、平均动脉压则进一步下降,于第8周收缩压和舒张压均降至正常,与治疗前比较差异有统计学意义(P<0.01)。结论非洛地平联合厄贝沙坦治疗老年性高血压病,降压平稳,不良反应小,疗效明显。
Objective To observe the clinical efficacy of felodipine combined with irbesartan in the treatment of senile hypertension. Methods The author’s hospital from May 2009 to May 2011 admitted to 56 cases of senile essential hypertension, oral sustained-release tablets of felodipine 5mg / d, combined irbesartan 150mg / d, the morning of a meal treatment , Treatment for 8 weeks. Observed during treatment of blood pressure, heart rate and adverse reactions. Results After treatment, systolic blood pressure (SBP), diastolic blood pressure (DBP) and mean arterial pressure (MAP) in the 4th week of patients were significantly lower than those before treatment (P <0.05). Systolic blood pressure, diastolic blood pressure and mean arterial pressure decreased further with prolonged course of treatment. Systolic blood pressure and diastolic blood pressure decreased to normal at 8 weeks, with statistical significance (P <0.01). Conclusion Felodipine combined with irbesartan in the treatment of senile hypertension, stable blood pressure, adverse reactions, and obvious curative effect.