At present,depression is treated with antidepressant drugs and assisted with psychotherapy and physical therapy,and these expensive and time-consuming treatment methods often end prematurely and result in a prolonged course without effective symptom relief.Therefore,based on the neurofeedback therapy,a novel depression rehabilitation method using a Virtual-Reality (VR) game framework is proposed.In this VR game framework,an innovative three-electrode Electroencephalography (EEG) collector is used to record patients’ EEG data.The data are processed and converted into feedback features,and the feedback will be displayed to patients in real time through a VR headset.Patients can adjust their psychological activity based on the feedback,and relieve their physiological dysfunction effectively.The framework also provides a data storage module,which may offer therapists ways to assess patients’ rehabilitation results in a long term,as well as provide possibility to continue towards better algorithm of feedback features with data-mining.The prototype system is tested in the framework,and the experimental results prove the effectiveness of the framework in depression rehabilitation.