例1,女,70岁,因咳嗽咳痰10余年,加重1周,诊为慢性支气管炎急性发作而于1995年12月2日入院,入院时体温为38℃,入院后给予头孢噻后钠4gqd静滴,体温在3天后降至正常。入院第7天体温又升高至38℃,第9天升高至39℃,以下午为明显,表现为弛张热,伴有恶寒、全身酸痛、食欲减退。查体除两肺可闻及散在干性啰音外无其它阳性体征,无皮疹等皮肤损害表现。查血尿便常规、外周血细胞形态、找疟原虫、血培养、肥达氏反应、全胸片、上腹部B超等均无异常,排除再感染及二重感染以及其它药物过敏的可能后,考虑为头孢噻肟钠所致药物热,于停用头孢噻肟钠后第2 Case 1, female, 70 years old, due to cough and sputum for more than 10 years, an increase of 1 week, was diagnosed with acute exacerbation of chronic bronchitis and admission in December 2, 1995, admitted to the body temperature of 38 ℃, after admission cefotaxime sodium 4gqd intravenous infusion, body temperature dropped to normal after 3 days. On the 7th day after admission, the body temperature increased to 38 ° C again. On the 9th day, the body temperature increased to 39 ° C, which was evident in the afternoon. It showed relaxation heat accompanied by aversion to cold, body aches and loss of appetite. Physical examination in addition to the two lungs can be heard and casual dry rales outside no other positive signs, no skin rash and other rash performance. Check the hematuria routine, peripheral blood cell morphology, looking for malaria parasite, blood culture, Widal reaction, chest X-ray, abdominal ultrasound B were no exception, rule out re-infection and double infection and other drug allergies may be considered Cefotaxime sodium-induced drug fever, cefotaxime stopped after the first 2