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ＭＨＣ在肿瘤免疫方面起着重要作用，恶性肿瘤细胞常有ＭＨＣ表达降低或丢失。干扰素可使ＭＨＣ表达降低或丢失恶性肿瘤细胞ＭＨＣ表达增强，也可使ＭＨＣ表达无降低或丢失的恶性肿瘤细胞的ＭＨＣ表达进一步增强，从而增强肿瘤的免疫原性，这在肿瘤的免疫治疗中具有重要意义。干扰素通过加速细胞ＭＨＣ转录过程，增强其表达。
MHC plays an important role in tumor immunity. Malignant tumor cells often have reduced or lost MHC expression. Interferon can increase or decrease the expression of MHC in malignant tumor cells with reduced or lost MHC, and further enhance the expression of MHC in malignant tumor cells with no decrease or loss of MHC expression, thereby enhancing the immunogenicity of tumors, which is in the immunotherapy of tumors. It is of great significance. Interferons enhance their expression by accelerating the cellular MHC transcription process.