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目的 探索尿石症发病的危险因素 ,为人群预防提供依据。方法 选取深圳市尿石症现况调查发现的 334例患者为病例组 ,72 1名健康者为对照组 ,进行尿石症危险因素人群病例对照研究 ;采用非条件logistic回归对 34个变量进行分析 ,采用Falconer回归法估算遗传度。结果 尿石症病例组和对照组配比条件均衡可比 ,单因素logistic回归分析共有 17个变量有统计学意义 ,但最终进入模型的因素有 10个 ,其中 4个变量为尿石症发病危险因素 ,OR值大小依次为既往泌尿系慢性炎症史 (OR =4 .0 9,95 %CI :1.38～ 12 .14 )、一级亲属尿石症史 (OR =2 .6 1,95 %CI :1.70～ 4 .0 1)和多食动物蛋白质 (OR =2 .14 ,95 %CI:1.71～ 2 .6 9)、暴露日照时间长 (OR =1.39,95 %CI :1.16～1.6 6 ) ;而较高文化程度 (OR =0 .4 6 ,95 %CI :0 .2 9～ 0 .73)、日引水量多 (OR =0 .5 9,95 %CI :0 .4 8～0 .72 )、饮果汁 (OR =0 .4 1,95 %CI :0 .18～ 0 .94 )、多食奶及奶制品 (OR =0 .82 ,95 %CI :0 .6 8～0 .99)、多食蔬菜 (OR =0 .70 ,95 %CI:0 .5 5～ 0 .91)和多食水果 (OR =0 .78,95 %CI :0 .6 4～ 0 .94 ) 6个变量为尿石症发病的保护因素。一级亲属尿石症患病率病例组高于对照组 ,尿石症分离比为0 .0 10 9,95 %CI:0 .0 0 5 0～ 0 .0 1
Objective To explore the risk factors of urolithiasis and provide evidence for population prevention. Methods A total of 334 patients with urolithiasis were selected as the case group and 72 healthy controls as the control group. The case-control study of risk factors for urolithiasis was performed in this study. 34 variables were analyzed using unconditional logistic regression Falconer regression was used to estimate the heritability. Results The proportion of patients with urolithiasis was comparable to that of the control group. There were 17 variables in the single-factor logistic regression analysis, but there were 10 factors that eventually entered the model, of which 4 variables were risk factors for urolithiasis (OR = 4.09, 95% CI: 1.38-12.12), first-degree relatives history of urolithiasis (OR = 2.6%, 95% CI: (OR = 1.14, 95% CI: 1.71-2.69) and long exposure time (OR = 1.39, 95% CI: 1.16-1.66). The higher level of education (OR = 0.46, 95% CI: 0.929-0.73) led to more daily water diversion (OR = 0.59, 95% CI: 0.48-0.4). (OR = 0.82, 95% CI: 0.68 ~ 0.72) in drinking milk and milk products (OR = 0.94, 95% CI: 0.18 ~ 0.94) (OR = 0.70, 95% CI: 0.55-0.91) and more fruits (OR = 0.78, 95% CI: 0.664-0.94) Six variables for the incidence of urolithiasis protective factors. The prevalence of urolithiasis in first degree relatives was higher than that in control group, and the urinary stone segregation ratio was 0.010 9, 95% CI: 0.0050-0.0.01