More than 2 million new ischemic stroke patients are diagnosed every year in China, with a prevalence of about 11 million.Stroke is the leading cause of death in the country [1, 2].The therapeutic effect on ischemic stroke in the ultra-early period depends on the timely restoration of the blood supply to rescue brain tissue.The current guidelines recommend that patients should be treated with intravenous thrombolysis within 4.5 h after symptom onset.Even for patients with large artery occlusion suitable for mechanical thrombectomy, intravenous thrombolysis has the advantages of a rapid start-up, increasing the chance of recanalization and improved microcirculatory function [3].However, thrombolysis therapy has limitations, including a higher risk of hemorrhage transformation and higher cost, as well as the possibility of occlusion in distal vessels if the clot breaks into pieces.Therefore, neurologists have been trying to determine whether intravenous thrombolysis can be skipped to perform mechanical thrombectomy directly.