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目的探讨重组ＩＦＮ－γ用作血吸虫抗原佐剂的可能性。方法用ｒｅＳｊ２６ＧＳＴ加鼠重组ＩＦＮ－γ，ｒｅＳｊ２６ＧＳＴ加福氏佐剂以及ＩＦＮ－γ分别免疫ＢＡＬＢ／ｃ 小鼠，攻击感染后４５ｄ解剖小鼠，比较各组小鼠成虫检获数及克肝卵数。结果ＩＦＮ－γ／ＧＳＴ组小鼠的减虫率和减卵率均略高于ＦＣＡ／ＧＳＴ组。结论ＩＦＮ－γ可以增强ｒｅＳｊ２６ＧＳＴ保护性免疫效果，初步提示ＩＦＮ－γ可作为血吸虫抗原佐剂使用。
Objective To investigate the possibility of using recombinant IFN-γ as an adjuvant for schistosome antigen. Methods BALB / c mice were immunized with reSj26GST plus murine recombinant IFN-γ, reSj26GST plus Freund’s adjuvant and IFN-γ, respectively. The mice were dissected 45 days after infection and the number of seized mice and the number of gram-oocytes were compared. Results The worm reduction rate and the oviposition rate of IFN-γ / GST group were slightly higher than those of FCA / GST group. Conclusion IFN-γ can enhance the protective immunity effect of reSj26GST. It is suggested that IFN-γ may be used as an adjuvant for schistosome antigen.