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结核性脑膜炎(TBM)是最严重的肺外结核病,发展中国家的结核病例中此病的发生率为7～12％。由于脑脊液中(CSF)结核茵很少,涂片不易检出,培养又需时6～8周,因此早期诊断常为推测性。本文报道用聚合酶链反应(PCR)检测CSF标本的结果,并与常规细菌学及酶联免疫吸附试验(ELISA)等检测结果进行比较。病例组为34例疑诊为TBM的患者,对照组为51例非TBM患者。TBM临床诊断标准为:发热、头痛及颈项强直持续2周以上。支持证据通过下列检查获得:(1)CSF中淋巴细胞>0.02×10~9/L,蛋白>
Tuberculous meningitis (TBM) is the most serious extra-pulmonary tuberculosis, and tuberculosis in developing countries the incidence of this disease is 7 to 12%. Because cerebrospinal fluid (CSF) tuberculosis is very small, smear is not easy to detect, culture takes 6 to 8 weeks, so early diagnosis is often speculative. This article reports the results of polymerase chain reaction (PCR) detection of CSF samples and compared with conventional bacteriological and enzyme-linked immunosorbent assay (ELISA) and other test results. The 34 patients in the case group were suspected TBM patients and the 51 patients in the control group were non-TBM patients. TBM clinical diagnostic criteria: fever, headache and neck stiffness for more than 2 weeks. Supporting evidence was obtained by the following examinations: (1) lymphocytes in CSF> 0.02 × 10 ~ 9 / L, protein>