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5. Synthesis of mono-substituted derivatives of 6-aminoquinoline

Synthesis of mono-substituted derivatives of 6-aminoquinoline

来源 :中国化学快报（英文版） | 被引量 : 0次 | 上传用户：wangzhujiaqiao

【摘 要】

：

Several 6-aminoquinoline derivatives, which could be used in drug design, have been synthesized. The reaction conditions were comparatively studied, and the p-c

【作 者】

：

Tian Lan Xian Xia Yuan Jiang H 

【机 构】

：

School of Chemistry and Chemical Engineering, School of Pharmacy, Xinchang Pharmaceutical Factory

【出 处】

：

中国化学快报（英文版）

【发表日期】

：

2004年期

【关键词】

：

6-Aminoquinoline 6-Nitroquinoline Skraup reaction Oxidant 

【基金项目】

：

The National Science Foundation of China;The 973 Program of China;The STCSM of China;The Foundation of Zhejiang Pharmaceutics Co.Ltd;The Opening Foundation of Zhejiang Provincial Top Key Discipline

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Several 6-aminoquinoline derivatives, which could be used in drug design, have been synthesized. The reaction conditions were comparatively studied, and the p-chloroaniline was used as optimum oxidant in Skraup-Doebner-Von Miller reaction. The nitro group was reduced effectively by SnCl2 with no halo-removed occurred.

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