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目的探讨前列舒通抑制良性前列腺增生的治疗作用机理,观察其对良性前列腺增生的治疗效果。方法观察前列舒通作用于丙酸睾酮诱导去势大鼠前列腺增生模型后的前列腺指数,前列腺体积,前列腺腺体总面积、bFGF(碱性成纤维生长因子)、EGF(表皮生长因子)、bcl-2(抑制细胞凋亡因子),以及前列腺组织病理学改变。结果前列舒通各浓度组前列腺指数、前列腺体积、前列腺腺体总面积、bFGF、EGF、bcl-2均明显低于模型组。结论前列舒通能显著抑制丙酸睾酮诱导去势大鼠的良性前列腺增生,其机制可能是通过降低bFGF、EGF、bcl-2的表达水平,从而抑制前列腺细胞增殖和促进凋亡而实现的。
Objective To investigate the therapeutic mechanism of Qianlieshutong inhibiting benign prostatic hyperplasia and observe its therapeutic effect on benign prostatic hyperplasia. METHODS: Prostate index, prostate volume, total prostate gland area, bFGF (basic fibroblast growth factor), EGF (epidermal growth factor), bcl, were measured after prostate intervention with testosterone propionate. -2 (inhibits apoptosis), and histopathological changes in the prostate. Results The prostate index, prostate volume, total prostate gland area, bFGF, EGF and bcl-2 were significantly lower in the former group than those in the model group. Conclusion Prostaglandin can significantly inhibit benign prostatic hyperplasia induced by testosterone propionate in ovariectomized rats. The mechanism may be achieved by reducing the expression of bFGF, EGF and bcl-2, thereby inhibiting prostatic cell proliferation and promoting apoptosis.