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目的探讨抗生素对新生儿交叉配血试验的影响性。方法对234例纠正贫血的新生儿进行卡式抗人球蛋白法和盐水介质的交叉配血试验,并通过查阅病历收集其同期的用药史,分析交叉配血实验与抗生素使用情况的关系。结果 234例纠正贫血的新生儿病例中,盐水介质交叉配血全部成功,即全部阴性;卡式抗人球蛋白法交叉配血不成功42例,即阳性率为17.9%;用药时间与交叉配血实验相关性差异有统计学意义(P<0.01)。结论药物性抗体在盐水介质中不能检出,随用药时间的延长产生药物性抗体,会增加红细胞致敏,导致交叉配血不合。
Objective To investigate the influence of antibiotics on neonatal cross-matching test. Methods A total of 234 anemia-corrected newborns were tested for cross-matching of anti-human globulin and saline media. The history of cross-matching with antibiotics was analyzed by referring to the medical records. Results In 234 cases of neonates ameliorating anemia, all the cross-matching of saline medium was successful, that is, all were negative. In 42 cases, the anti-human globulin cross-matching was unsuccessful, that is, the positive rate was 17.9% There was significant difference in blood experiment (P <0.01). Conclusion The drug-resistant antibody can not be detected in saline medium. With the prolongation of drug-use time, drug-induced antibody can increase the sensitization of erythrocytes, resulting in cross-matching of blood.