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目的 :探讨前列腺素 E1 对老年糖尿病肾病的疗效。方法 :将 6 8例糖尿病肾病患者随机分为治疗组 (38例 )和对照组 (30例 ) ,治疗组为对照组基础上予前列腺素 E1 90 ug静脉点滴 ,每日一次 ,共用 2 1d。结果 :治疗组早期糖尿病肾病 2 4 h尿白蛋白排泄率和临床期糖尿病肾病 2 4 h尿蛋白定量较治疗前及与对照组相比明显降低。结论 :前列腺素 E1 是治疗老年糖尿病肾病是一种安全、有效的药物。
Objective: To investigate the effect of prostaglandin E1 on senile diabetic nephropathy. Methods: Sixty-eight patients with diabetic nephropathy were randomly divided into treatment group (n = 38) and control group (n = 30). The treatment group was treated with 90 ug prostaglandin E1 intravenously once a day for 21 days. Results: The excretion rate of urinary albumin in 24 hours of diabetic nephropathy patients and urinary protein in 24 hours of clinical diabetic nephropathy patients in treatment group were significantly lower than those before treatment and control group. Conclusion: Prostaglandin E1 is a safe and effective drug for the treatment of diabetic nephropathy in the elderly.