论文部分内容阅读
本文报告了维生素C(Vc)对甲基胆蒽(MC)诱发小鼠腺胃癌的抑制作用。LACA鼠100只,分成3组,MC组腺胃穿挂含MC的线结;Vc组处理同上,饮水中补充Vc;对照组腺胃只穿挂不含MC的线结。MC组总诱癌率为65.9％,Vc组为27.8％(P<0.02)。Vc组腺胃肿块、腺瘤样增生发生率亦较MC组为低(P<0.05),说明Vc有抑制MC诱发小鼠腺胃癌的作用。通过尾血淋巴细胞ANAE染色,观察到Vc组淋巴细胞ANAE阳性率比MC组下降得少,恢复快而彻底,提示Vc对小鼠免疫功能有保护和促进恢复的作用。
This article reported the inhibitory effect of vitamin C (Vc) on methyl gallocyst (MC)-induced gastric adenocarcinoma in mice. One hundred mice with LACA were divided into 3 groups. The MC group had glandular gastric loops that contained MC. The Vc group was treated as above and the drinking water was supplemented with Vc. The control group had glands and stomachs that were only wearing MC-free knots. The total cancer-inducing rate was 65.9% in the MC group and 27.8% in the Vc group (P<0.02). The incidence of glandular mass and adenomatous hyperplasia in the Vc group was also lower than that in the MC group (P<0.05), indicating that Vc inhibited MC-induced gastric adenocarcinoma in mice. Through ANAE staining of tail blood lymphocytes, it was observed that the positive rate of ANAE in lymphocytes in Vc group was less than that in MC group, and the recovery was rapid and thorough, suggesting that Vc has protective effects on immune function and promotes recovery of mice.