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目的 :评价全身伽玛刀治疗体部恶性肿瘤的近期疗效。方法 :2 0 0 1年 4月～ 2 0 0 2年 10月治疗体部肿瘤 12 4例 (15 9个病变部位 ) ,12 2例获得随访。肿瘤的临床靶体积 (CTV ) 2 76～ 972 6cm3 (平均为 198 3cm3 ) ,处方剂量 2～6 6Gy ,分 6～ 14次行放射治疗 ,总量 2 4～ 5 2Gy。结果 :所有患者顺利完成治疗。近期疗效按实体瘤疗效评价标准 ,完全缓解 (CR) 5 0例 ,部分缓解 (PR) 5 6例 ,无变化 (NC) 11例 ,进展 (PD) 5例 ,肿瘤控制总有效率为 86 89%。结论 :全身伽玛刀治疗体部恶性肿瘤近期效果满意 ,不良反应轻微 ,远期疗效和晚期并发症有待进一步随访观察。
Objective: To evaluate the short-term effect of whole body gamma knife in the treatment of malignant tumors in the body. Methods: From April 2001 to October 2002, 124 cases of body tumors (15 9 lesions) were treated, and 122 cases were followed up. The clinical target volume (CTV) of tumor ranged from 76 to 972 6 cm 3 (average 198 3 cm 3). The prescribed dose was from 2 to 6 6 Gy. The total tumor volume was 24 to 5 2Gy. Results: All patients completed the treatment successfully. The recent curative effect was evaluated according to the standard of curative effect of solid tumors. There were 50 cases of complete remission (CR), 56 cases of partial remission (PR), 11 cases of no change (NC) and 5 cases of progression (PD). The total effective rate of tumor control was 86 89 %. Conclusion: The whole body gamma knife treatment of malignant tumors in vivo short-term results are satisfactory, minor adverse reactions, long-term efficacy and advanced complications need further follow-up observation.