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目的 :评价泮托拉唑治疗十二指肠溃疡的疗效。方法 :共 10 0例活动期十二指肠溃疡患者 ,随机分为泮托拉唑治疗组和兰索拉唑对照组。用药 4周后复查胃镜 ;采用积分法记录治疗前后患者的症状 ;记录治疗期间出现的不良反应。结果 :治疗组临床症状积分与对照组积分无显著差异 (P >0 .0 5 ) ;疼痛缓解时间分别为 (2 .5± 0 .8)和 (2 .4± 0 .5 )d ,P >0 .0 5 ;两组治疗 4周后胃镜检查结果分别为 :痊愈 44例 (88% )和 43例 (86 % ) ,显效率 92 %和88% ,总有效率 98%和 96 % ,两组间无显著差异 (P >0 .0 5 ) ;未出现严重不良反应。结论 :泮托拉唑 40mg治疗十二指肠溃疡 ,其疗效与兰索拉唑 30mg相似 ,具有促进溃疡愈合、不良反应少的优点
Objective: To evaluate the efficacy of pantoprazole in the treatment of duodenal ulcer. Methods: A total of 10 patients with active duodenal ulcer patients were randomly divided into pantoprazole treatment group and lansoprazole control group. Gastroscopy was performed after 4 weeks of treatment. The symptom before and after treatment was recorded by the integral method. The adverse reactions during treatment were recorded. Results: There was no significant difference in scores of clinical symptoms between the treatment group and the control group (P> 0.05), pain relief time was (2.5 ± 0.8) and (2.4 ± 0.5) days, P The results of gastroscopy were 44 cases (88%) and 43 cases (86%) cured after 4 weeks of treatment, the effective rates were 92% and 88%, the total effective rate was 98% and 96%, respectively No significant difference between the two groups (P> 0.05); no serious adverse reactions. Conclusion: The treatment of duodenal ulcer with pantoprazole 40mg has the same curative effect as lansoprazole 30mg, which has the advantages of promoting ulcer healing and less adverse reactions