熊去氧胆酸简称 UDCA,1927年由日本 Shcda 首先分离得到结晶,1937年确定其结构,1957年被收载入日本药局方(第八改正版)。UDCA 起初用作利胆剂,近年来用于治疗胆固醇胆结石,但对于治疗不透 X 射线的胆石及胆红素胆石不适合。本品作用的机理是减少胆汁胆固醇的分泌,降低胆固醇相对于胆酸的饱和度,使胆石表面的胆固醇慢慢地溶解。此外,本品还可用于急、慢性肝炎、肝硬变,高脂血症等的治疗。 Ursodeoxycholic acid referred to as UDCA, 1927 by the Japanese Shcda first isolated crystals, 1937 to determine its structure, was incorporated into the Japanese Pharmacopoeia in 1957 (eighth revised edition). UDCA was originally used as a cholagogue and has been used in recent years to treat cholesterol gallstones but is not suitable for the treatment of radiopaque gallstones and bilirubin gallstones. The mechanism of action of this product is to reduce the secretion of bile cholesterol, reduce the saturation of cholesterol relative to bile acid, so that the gallstone surface cholesterol slowly dissolves. In addition, the product can also be used for acute and chronic hepatitis, cirrhosis, hyperlipidemia and other treatment.