论文部分内容阅读
目的探讨不同地区非接触汞正常人群尿汞正常值。方法在上海、黑龙江、广东、四川等省市,收集非接触汞正常人群尿样共2 248例。样本采集采用随意尿,统一使用聚乙烯塑料瓶收集不少于25ml的尿样,统一使用上海光华仪器厂生产的F732-G型测汞仪,测定方法采用尿中汞的酸性氯化亚锡还原-冷原子吸收法和尿中汞的碱性氯化亚锡还原-冷原子吸收法。并用肌酐和比重校正。采用苦味酸法测定肌酐,采用比重计测定比重。结果尿汞测定值呈偏态分布,采用对数转换成正态或近似正态分布,用几何均数表示平均水平。酸性法和碱性法2种测定方法的比较,差异无统计学意义(P=0．099)。男女间各地区比较,差异无统计学意义(P＞0．05)。尿汞正常值95%上限为≤4．25μg/L(21．22 nmol/L),用肌酐校正后为3．724 5μg/g Cr(18．38 nmol/g Cr),比重校正后为4．45μg/L (22．50 nmol/L)。结论建议尿汞正常参考值为≤5μg/L(25 nmol/L),肌酐校正后为≤4μg/L Cr(20 nmol/Cr),比重校正后为≤5μg/L(25 nmol/L)。
Objective To investigate the urinary mercury normal value in non-contact mercury normal population in different areas. Methods A total of 2 248 urinary samples from non-contact mercury normal population were collected in Shanghai, Heilongjiang, Guangdong and Sichuan provinces. Samples collected using random urine, uniform use of polyethylene plastic bottles to collect not less than 25ml of urine samples, uniform use of Shanghai Guanghua Instrument Factory F732-G-type mercury analyzer, determination of urinary mercury acid stannous chloride reduction Cold atomic absorption spectrometry and alkaline stannous chloride reduction in urine - Cold atomic absorption spectrometry. And with creatinine and gravity correction. Determination of creatinine by picric acid method, using a hydrometer to determine the proportion. Results Urine mercury measured values were skewed distribution, the use of logarithms into normal or approximate normal distribution, with the geometric means that the average level. There was no significant difference between the two methods of acid and alkaline methods (P = 0.099). There was no significant difference between men and women in all regions (P> 0.05). The upper limit of 95% normal urinary mercury was ≤4.25 μg / L (21.22 nmol / L), corrected to creatinine was 3.724 5 μg / g Cr (18.38 nmol / g Cr) .45 μg / L (22.50 nmol / L). Conclusions The recommended urinary mercury normal reference value is ≤5μg / L (25 nmol / L), creatinine ≤4μg / L Cr (20 nmol / Cr) after calibration and ≤5μg / L (25 nmol / L) after calibration.