重度Graves病突眼目前尚无肯定的药物治疗方法。作者用强的松和环孢素A治疗36例有重度眼部病变而甲状腺功能正常的Graves病人。为比较两药的效果,病人随机分为两组,病情相似。第1组先用强的松60mg和40mg各2周,再用30mg和20mg各4周;第2组用环孢素A7.5mg/kg/d。若出现血肌酐浓度增高或用硝苯吡啶不能控制的高血压,则调整剂量。治疗12周时眼部症状无好转的病人改 Severe Graves disease exophthalmos there is no sure drug treatment. The authors used prednisone and cyclosporine A to treat 36 Graves patients with severe ocular lesions and normal thyroid function. To compare the efficacy of the two drugs, patients were randomized into two groups with similar illness. The first group with prednisone 60mg and 40mg each 2 weeks, then 30mg and 20mg each 4 weeks; the second group with cyclosporine A7.5mg / kg / d. If there is increased serum creatinine or nifedipine can not control the hypertension, then adjust the dose. Treatment of patients with eye symptoms did not improve after 12 weeks of change