妊娠动物一次投予大剂量锂盐或抗精神病药对胎仔有明显致畸作用,可出现唇裂、腭裂、发育迟缓、无脑畸形及肢体畸形等。孕妇妊娠早期服用这类药物时,畸形儿发生率增高。可见双侧畸形足、腰脊膜膨出、外耳道畸形、上颌骨发育不全,心血管畸形和无脑畸形等。分析了致畸作用的可能因素。提出孕妇妊娠头3mo尽量避免使用这些精神药物。 Pregnant animals once administered large doses of lithium salt or antipsychotics have significant teratogenic effects on the fetus, there may be cleft lip, cleft palate, growth retardation, anencephaly and limb deformities. Pregnant women taking such drugs early pregnancy, the incidence of deformed children increased. Visible bilateral deformity foot, lumbar spinal bulge, external auditory canal malformation, maxillary hypoplasia, cardiovascular malformations and anencephaly. The possible causes of teratogenicity were analyzed. Put forward the first 3 months pregnant women try to avoid the use of these psychotropic substances.