论文部分内容阅读
目的 采用前瞻随机分组研究 ,探讨野中野加速超分割放疗能否提高胸段食管癌的疗效。方法 1992年6月至 1993年 12月 ,6 9例胸段食管癌随机分组 ,野中野加速超分割治疗组 34例 ,常规治疗组 35例 ,两组患者一般临床资料差异无统计学意义。放射总剂量常规组 6 5Gy± 2 .1Gy ,照射 33次 /45天 ,野中野组总剂量 6 5Gy± 1.6Gy ,2 3次 /34天。结果 急性放射性食管炎发生率常规组 17% ,野中野组 38%。常规组 1、3、5年生存率分别为 :5 1.4%、2 0 %、14 .3 % ,而野中野组分别为 70 .5 %、44.12 %、2 6 .5 % (3年生存率差异显著P <0 .0 5 )。结论 野中野加速超分割放疗胸段食管癌患者可耐受 ,并且提高了长期生存率。
Objective To study the effect of accelerating hyperfraction radiotherapy on thoracic esophageal cancer by prospective randomized study. Methods From June 1992 to December 1993, 67 cases of thoracic esophageal cancer were randomly divided into three groups. 34 cases were treated by accelerated field fractionation and 35 cases were treated by routine therapy. There was no significant difference in general clinical data between the two groups. The total radiation dose was 6 5Gy ± 2. 1Gy in the conventional group and 33/45 days in the irradiation group. The total dose in the wild group was 65Gy ± 1.6Gy and 23/34 days. Results The incidence of acute radiation esophagitis was 17% in routine group and 38% in Nakano group. The 1, 3, 5-year survival rates of the conventional group were respectively 5 1.4%, 20% and 14.3%, compared with 70.5%, 44.12% and 26.5% (3-year survival rate The difference was significant P <0. 05). Conclusion Nakano field accelerated hyperfractionation radiotherapy thoracic esophageal cancer patients can tolerate, and improve the long-term survival rate.