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目的对比克罗米芬(clomiphene,CC)与来曲唑(letrozole,LE)用于多囊卵巢综合征(polycystic ovarian system,PCOS)患者促排卵治疗的效果。方法选择2012年1月—2013年8月就诊的排卵障碍为唯一不孕因素的PCOS患者83例,CC组45例,LE组38例,分别于月经,或者撤退出血第3天给予克罗米芬50 mg,LE 2.5 mg口服促排卵治疗。计量资料采用t检验,计数资料采用χ2检验,,P<0.05为差异有统计学意义。结果 CC组HCG日内膜(7.66±1.15)mm,LE组(9.34±1.02)mm,两组比较差异有统计学意义(P<0.05)。两组排卵率、妊娠率、卵巢过度刺激综合征(ovarian hyperstimulation syndrome,OHSS)发生率比较差异均无统计学意义(均P>0.05)。CC组多胎妊娠率22.22%,LE组多胎妊娠率5.26%,比较差异有统计学意义(P<0.05)。结论 LE用于PCOS患者促排卵治疗对于子宫内膜无明显不良影响,多胎妊娠率低于CC组,是一种安全、有效、经济的促排卵药物。
Objective To compare the effects of clomiphene (CC) and letrozole (LE) on ovulation induction in patients with polycystic ovarian system (PCOS). Methods Eighty-three PCOS patients with ovulation disorder as the only infertility treatment from January 2012 to August 2013 were enrolled. 45 cases of CC and 38 cases of LE were enrolled in this study. Clomiphene 50 mg, LE 2.5 mg orally ovulation therapy. Measurement data using t test, count data using χ2 test, P <0.05 for the difference was statistically significant. Results In HC group, the endometrial thickness was (7.66 ± 1.15) mm in HC group and (9.34 ± 1.02) mm in LE group, the difference was statistically significant (P <0.05). There were no significant differences in ovulation rate, pregnancy rate and ovarian hyperstimulation syndrome (P> 0.05) between the two groups. The multiple pregnancy rate was 22.22% in CC group and 5.26% in LE group, with significant difference (P <0.05). Conclusions LE for ovulation induction in PCOS patients has no obvious adverse effect on endometrium, and the multiple pregnancy rate is lower than CC group, which is a safe, effective and economical ovulation promoting drug.