皮肤着色真菌病常难以治疗。作者报道一例用酮康唑和5-FC成功的病例:男性,43岁,左腿疣状和瘢痕性皮损4年。呈皮下结节,伴有皮肤萎缩斑,轻碰即可出血。活检为肉芽肿和发现真菌,培养出裴氏着色真菌。遂用酮康唑治疗(200mg/日),治疗8周不见改善,加量至400mg/日。1个月后病人股部出现新的结节皮损。试管内研究:酮康唑的最低抑菌浓度(MIC)为8μg/ml,5-FC的MIC为128 Skin coloring fungal disease often difficult to treat. The authors report a case of successful cases with ketoconazole and 5-FC: male, 43 years old, left leg verrucous and cicatricial lesions for 4 years. Subcutaneous nodules, accompanied by skin atrophy, flip can be bleeding. Biopsy for granulomas and found in fungi, cultured Pei colored fungi. Then with ketoconazole treatment (200mg / day), 8 weeks of treatment no improvement, dosage to 400mg / day. One month later, new nodular lesions appeared in the patient’s thighs. In vitro studies: The minimum inhibitory concentration (MIC) of ketoconazole was 8 μg / ml and the MIC of 5-FC was 128