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目的 :比较早发性 (起病年龄 <5 0岁 )帕金森病 (PD)与晚发性 (起病年龄≥ 5 0岁 )PD的异同 ,判断它们是否为同一疾病体。方法 :将 5 2例早发性PD与 168例晚发性PD进行家族史和临床表现的比较 ,后者包括UPDRSⅡ、UPDRSⅢ、Hoehn&Yahr分级。结果 :早发性PD中有阳性家族史者共 10例 (占 19 2 % ) ,显著高于晚发性PD(共 7例 ,占 4 2 % )。两组之间的上述各临床评分无显著差异。结论 :早发性PD与晚发性PD系同一疾病体。遗传因素在早发性PD中可能起重要作用。
OBJECTIVE: To compare the similarities and differences between PD (onset age <50 years) and PD (onset age ≥50 years) and to determine if they are the same disease. Methods: A comparison of family history and clinical features was performed in 52 cases of early-onset PD and 168 cases of late-onset PD, the latter including UPDRS II, UPDRS III, Hoehn & Yahr grading. Results: There were 10 cases (19.2%) with positive family history of PD in early-onset PD, which was significantly higher than that of late onset PD (7 cases, 42%). There was no significant difference in the above clinical scores between the two groups. CONCLUSIONS: Early onset PD is the same disease as late-onset PD. Genetic factors may play an important role in early-onset PD.