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目的测定血清肿瘤坏死因子α(TNF-α)、白细胞介素-10(IL-10)变化，了解糖尿病酮症酸中毒合并全身炎症反应综合征(SIRS)的病情变化。方法选取我院接诊糖尿病酮症酸中毒患者36例，其中15例合并有SIRS，21例未合并SIRS。测定TNF-α、IL-10。结果 SIRS组24 h、7 d TNF-α、IL-10测定结果与No-SIRS组比较明显较高(<0.05)。结论在糖尿病酮症酸中毒合并SIRS与TNF-α、IL-10有关。“,”Objective To determine the serum tumor necrosis factor alpha (TNF alpha),leukocyte mediated IL-10 (IL-10)change,to understand the syndrome of diabetic ketoacidosis complicated with systemic inflammatory response syndrome(SIRS)condition changes.Methods A total of 36 cases of diabetic ketoacidosis patients in our hospital,including 15 cases with SIRS,21 cases without SIRS.Determination of TNF-alpha,IL-10.Results SIRS group,24h,7dTNF-a,IL-10 compared with No-SIRS group were significantly higher ( <0.05).Conclusion In patients with diabetic ketoacidosis associated with TNF-alpha,IL-10 SIRS.