灭吐灵的副反应发生率<20％,在成人中偶可引起高泌乳血症的男性乳房发育和溢乳,但在儿童尚未见有报道。本文报道2例男性儿童用灭吐灵治疗胃食管返流病后出现的男性乳房发育。 例1:孕37周的新生男婴,患软骨发育不全,出生9天时见气管液中有咽下的钡剂而诊断为胃食管返流。原未扪及乳房组织。用灭吐灵治疗,开始每次0.1mg/kg,后增加到每次0.2mg/kg,一日4次,用药3周后检查见双侧萌芽样乳房直径4.0cm×3.5cm并伴溢乳,血清泌乳素37ng/ml(正常小儿3.6～12.0ng/ml)。停 The incidence of side effects of metoclopramide <20%, even in adults, can cause hyperprolactinemia in male breast development and galactorrhea, but has not been reported in children. This article reports the male breast development in 2 male children treated with metoclopramide after gastroesophageal reflux disease. Example 1: Newborn baby boy of 37 weeks pregnant with achondroplasia, who had swallowed barium in the tracheal fluid 9 days after birth was diagnosed as gastroesophageal reflux. The original palpable breast tissue. With metoclopramide treatment, each 0.1mg / kg, after each increase to 0.2mg / kg, 4 times a day, after 3 weeks of treatment see the germ-like double-sided breast 4.0cm × 3.5cm in diameter and with galactorrhea, Serum prolactin 37ng / ml (normal children 3.6 ~ 12.0ng / ml). stop