论文部分内容阅读
受传统方法精确度的限制,生产实践中辐照灭菌剂量的设定值往往超过产品的实际需要。多余的辐照剂量会对产品造成不必要的辐照损伤,同时也降低了辐照工厂的产能。本文通过理论研究证明,任一给定抗性分布的微生物种群存在一条非线性的“灭菌剂量曲线”。对于具有标准抗性分布(Standard distribution of resistances,SDR)的微生物种群,采用5种常用函数拟合其灭菌剂量曲线的结果表明,5次多项式函数的拟合程度最好。与传统使用线性函数拟合的方法相比,基于5次多项式函数拟合的灭菌剂量设定方法可以将所设定的灭菌剂量与理论值的偏差范围从-9.8%-123.1%缩小至-7.7%-1.9%。此方法可以在保证产品灭菌合格的基础上有效降低多余的辐照剂量。
Due to the limitation of the accuracy of the traditional method, the set value of the radiation sterilization dose in the production practice often exceeds the actual needs of the product. Excess radiation dose will cause unnecessary radiation damage to the product, but also reduce the production capacity of the irradiation plant. In this paper, theoretical studies have shown that there is a non-linear “sterilization dose curve” for the microbial population of any given resistance distribution. For the population of standard distribution of resistances (SDR), the results of fitting the sterilization dose curve with five commonly used functions show that the polynomial function of the 5th degree fits best. Compared with the traditional method of fitting the linear function, the method of setting the sterilization dose based on the fifth polynomial function fitting can reduce the deviation of the set sterilization dose from the theoretical value from -9.8% -123.1% to -7.7% -1.9%. This method can effectively reduce the excess radiation dose on the basis of ensuring the sterilization of the product.