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本文通过HPLC法对布洛芬和芬必得两种缓释胶囊达稳态后,血浆中布洛芬的药物动力学与相对生物利用度研究,观察缓释效果和波动系数,为临床提供合理的用药依据。
In this paper, the pharmacokinetics and relative bioavailability of ibuprofen in plasma were determined by HPLC after the two sustained-release capsules of ibuprofen and fenbid were steady-state, and the sustained-release effect and the fluctuation coefficient were observed to provide a reasonable Medication basis.