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目的：研究Ｐ１６蛋白与人脑髓母细胞瘤发病的关系。方法：应用ＳＰ免疫组化技术检测４５例术中切除的肿瘤标本的石蜡切片。结果：Ｐ１６蛋白在４５例髓母细胞瘤中的表达缺失率为８０％。而在１０例正常脑组织中的表达率为１００％。结论：Ｐ１６蛋白的缺失与髓母细胞瘤的发生有密切关系，其中的具体机制有待于在今后的研究中阐明。
Objective: To study the relationship between P16 protein and the pathogenesis of human brain medulloblastoma. Methods: SP immunohistochemical technique was used to detect paraffin sections of 45 specimens of intraoperatively resected tumors. Results: The deletion rate of P16 protein in 45 cases of medulloblastoma was 80%. In 10 cases of normal brain tissue, the expression rate was 100%. Conclusion: The deletion of P16 protein is closely related to the occurrence of medulloblastoma. The specific mechanism needs to be elucidated in future studies.