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VEGF是一种重要的促血管生成因子。肿瘤组织VEGF高表达可能为其继续生长和转移提供了内在必要条件。VEGF通过与内皮细胞和肿瘤细胞上的受体结合在肿瘤的发生、进展中发挥着重要作用。本文综述了VEGF及其受体与泌尿生殖系肿瘤生物学行为的关系的研究 ,并探讨了其在肿瘤的临床诊断和治疗中的应用前景。
VEGF is an important pro-angiogenic factor. High expression of VEGF in tumor tissue may provide the necessary conditions for its continued growth and metastasis. VEGF plays an important role in tumorigenesis and progression by binding to receptors on endothelial cells and tumor cells. This review summarizes the relationship between VEGF and its receptors and the biological behavior of genitourinary tumors, and explores its potential application in the clinical diagnosis and treatment of tumors.