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用免疫组化法检测正常甲状腺,未见HLA-DR抗原阳性的甲状腺上皮细胞(TEC),在所有被检Graves病(GD)甲状腺组织均可见到TEC不同程度地表达DR抗原。GD患者TEC DR抗原的表达水平与血清甲状腺刺激性抗体(TSAb)水平明显相关(r=0.357,P<0.05),提示GD患者血TSAb水平与异常表达DR的甲状腺上皮细胞有密切关系。
Immunohistochemistry was used to detect the normal thyroid gland. No HLA-DR antigen-positive thyroid epithelial cells (TECs) were detected. TECs showed different degrees of expression of the DR antigen in all the Graves’ disease (GD) thyroid tissues. The expression level of TEC DR antigen in patients with GD was significantly correlated with serum thyroid stimulating antibody (TSAb) levels (r = 0.357, P <0.05), suggesting that serum TSAb levels in patients with GD are closely related to thyroid epithelial cells with abnormally expressed DR.