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蛛网膜下腔插管大鼠模型２５只，随机等分为Ａ、Ｂ、Ｃ、Ｄ、Ｅ５组，分别经插管注入蝎毒素Ⅳ１μｇ／ｋｇ，纳络酮１６μｇ／ｋｇ＋蝎毒素Ⅳ１μｇ／ｋｇ，吗啡３２μｇ／ｋｇ，纳络酮１６μｇ／ｋｇ＋吗啡３２μｇ／ｋｇ，纳络酮１６μｇ／ｋｇ。以屈肌反射作为疼痛指标，观察蝎毒素Ⅳ在脊髓的镇痛作用及纳络酮对蝎毒素Ⅳ作用的影响并与吗啡进行对比观察。结果蝎毒素Ⅳ注入５～２０ｍｉｎ和９０～１２０ｍｉｎ内屈肌反射被显著抑制（Ｐ＜０．０１），表现为屈肌反射阈值升高及Ｃ波潜伏期延长；此种抑制不能被纳络酮消除。提示蝎毒素Ⅳ在脊髓具有一定的镇痛作用；其发挥镇痛作用的机制不同于吗啡。
A total of 25 rat models of subarachnoid intubation were randomly divided into groups A, B, C, D and E5. Intrathecal injection of scorpion toxin Ⅳ 1 μg / kg, naloxone 16 μg / kg + scorpion toxin Ⅳ 1 μg / kg, Morphine 32 μg / kg, naloxone 16 μg / kg + morphine 32 μg / kg, naloxone 16 μg / kg. The pain index of flexor muscle reflex was used to observe the analgesic effect of scorpion toxin IV in the spinal cord and the effect of naloxone on the scorpion toxin Ⅳ. Results Scorpion toxin Ⅳ was significantly inhibited at 5-20 min and 90-120 min after injection (P <0.01), showing increased reflex threshold and prolonged C-wave latency; this inhibition was not abolished by naloxone . Tip scorpion toxin Ⅳ in the spinal cord has a certain analgesic effect; its analgesic effect is different from the mechanism of morphine.