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目的:甲巯咪唑和丙硫氧嘧啶治疗甲亢后的不良反应对比研究。方法:抽取2013年2月至2014年10月在本院接受治疗的84例甲亢患者,随机分成甲组和乙组,各42例,其中甲组采取甲巯咪唑治疗,乙组采取丙硫氧嘧啶治疗,比较两组的不良反应发生率。结果:甲组血小板减少、红细胞减少、白细胞减少和皮疹发生率明显高于乙组(P<0.05);甲组肝功能损伤发生率明显低于乙组(P<0.05)。结论:利用甲巯咪唑治疗甲亢,会引起皮疹,血细胞减少;利用丙硫氧嘧啶治疗甲亢会损伤肝功能。
Objective: To compare the adverse reactions of methimazole and propylthiouracil after hyperthyroidism. Methods: Totally 84 patients with hyperthyroidism who were treated in our hospital from February 2013 to October 2014 were randomly divided into group A and group B, with 42 cases in each group, of which group A was treated with methimazole and group B was treated with propylthiourea Pyrimidine treatment, the incidence of adverse reactions in both groups were compared. Results: The incidence of thrombocytopenia, erythrocyte reduction, leukopenia and rash in group A was significantly higher than that in group B (P <0.05). The incidence of liver injury in group A was significantly lower than that in group B (P <0.05). Conclusion: The use of methimazole treatment of hyperthyroidism, can cause rash, cytopenia; the use of propylthiouracil treatment of hyperthyroidism will damage liver function.