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对呼吸功能衰竭患者不规则地进行高浓度氧气疗法,因造成早产儿视网膜症等氧中毒表现而受到评议。70年代由于出现呼气未正压呼吸(PEEP),使外周气道通畅,功能残气量增加,通气/血流比率得到改善,即使不给高浓度氧也能改善PaO_2。PEFP效果在重症呼吸功能衰竭者受到限制,不仅造成高压力损伤,而且因机械性人工呼吸时气道内压力高及大的压力振幅换气,反而损害肺自然治愈力,使医源性呼吸功能衰竭加剧。
Irregular high-concentration oxygen therapy for patients with respiratory failure has been criticized for causing oxygen toxicity such as retinopathy of prematurity. In the 1970s, due to the presence of non-positive expiratory pressure (PEEP), the peripheral airway was unobstructed, functional residual capacity was increased, and the ventilation / blood flow rate was improved. PaO2 was improved even without high concentrations of oxygen. PEFP effect in patients with severe respiratory failure is limited, not only causing high pressure damage, but also because of mechanical respiration in the airway pressure and large pressure amplitude ventilation, but damage the natural healing of the lungs, so that iatrogenic respiratory failure Exacerbated.