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甲苯二异氰酸酯(TDI)是制造聚氨、聚醚、聚苯等泡沫塑料的重要原料。近年来对其毒性以及发病原理文献中有较多的报导,现综述如下。临床及实验室资料TDI本身的毒性并不大,大鼠经口LD_(50)为5.8g/kg体重,吸入的致死量为600ppm六小时。但在工业生产中的危害很大,许多人由于呼吸道的炎症或明显的哮喘而降低劳动效率或失去劳动能力。造成这种情况的直接原因是肺功能的改变。经验证明TDI主要引起通气功能障碍,最大肺活量(FVC)下降,特别是一秒钟用力呼气量(FEV_1)下降,这种改变可以持续较长的时间,甚至每天工作结
Toluene diisocyanate (TDI) is to create polyurethane, polyether, polystyrene and other important raw materials foam. In recent years, its toxicity and pathogenesis literature has more reports, are summarized below. Clinical and laboratory data TDI itself is not toxic. The LD50 of rat is 5.8g / kg body weight and the lethal dose of inhalation is 600ppm for six hours. However, it is very harmful in industrial production. Many people reduce labor efficiency or lose their ability to work due to respiratory inflammation or obvious asthma. The direct cause of this is a change in lung function. Experience has shown that TDI mainly causes ventilatory dysfunction, a decrease in maximum vital capacity (FVC), especially a forced expiratory volume in one second (FEV_1), which can persist for longer periods of time and even work knots daily