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目的观察大容量肺灌洗术治疗尘肺患者的临床疗效及其对肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)的影响。方法采用肺灌洗治疗尘肺30例,于治疗前及治疗1周后分别行肺功能检查及TNF-α、IL-6检测,并与26例健康者进行比较。结果大容量灌洗后30例尘肺患者肺功能[用力肺活量(FVC)、1秒用力呼气量(FEV1)、最大通气量(MVV)、一氧化碳弥散量(DLCO)]较灌洗前明显改善(P<0.05),两组比较差异均有统计学意义(P<0.05)。30例尘肺患者灌洗前血清TNF-α、IL-6明显高于灌洗后及健康对照组,两组比较差异均有统计学意义(P<0.05)。结论大容量肺灌洗术治疗对尘肺是安全有效的方法,TNF-α、IL-6可以作为判断尘肺患者病情及疗效的指标。
Objective To observe the clinical efficacy of large-capacity lung lavage in patients with pneumoconiosis and its effect on tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6). Methods Lung lavage was used to treat 30 cases of pneumoconiosis. Before treatment and 1 week after treatment, pulmonary function tests, TNF-α and IL-6 levels were detected respectively and compared with 26 healthy controls. Results The lung function (FVC, FEV1, MVV, DLCO) in 30 patients with pneumoconiosis after large volume lavage was significantly improved compared with that before lavage (P < P <0.05), the differences between the two groups were statistically significant (P <0.05). Serum levels of TNF-α and IL-6 in laryngeal patients before pneumoperitoneum were significantly higher than those in lavage and healthy controls (P <0.05). Conclusion Large-volume lung lavage is a safe and effective method for the treatment of pneumoconiosis. TNF-α and IL-6 can be used as indexes to judge the condition and effect of pneumoconiosis.