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目的探讨血清细胞因子在肝移植术后乙型病毒性肝炎(HBV)复发患者中的作用。方法以2002年6月至2003年12月行肝移植术的393例患者中选择资料完整的 HBV 相关肝病进行肝移植的患者34例(14例复发,20例未复发)为研究对象,采用 ELISA 方法检测术前1周内及术后随访近3年时间 HBV 复发时患者血清 IL-10、TNF-α、IL-2和 INF-γ的水平,观察其变化规律。结果规律应用免疫抑制剂后,肝移植术后 HBV 复发组与未复发组血清 IL-10、INFγ和 TNF-α浓度有明显统计学差异,未复发组高于复发组,而 IL-2水平没有变化。结论 IL-10和 TNF-α可以作为提示肝移植术后 HBV 复发的实验指标,具有非侵袭性、检测快速、费用低廉的优点,易于临床推广。
Objective To investigate the role of serum cytokines in the relapse of patients with hepatitis B after liver transplantation. Methods From June 2002 to December 2003, 393 patients undergoing liver transplantation were enrolled in the study. 34 patients (14 recurrent and 20 non-recurrent) with HBV-related liver disease undergoing liver transplantation were enrolled. Methods The levels of IL-10, TNF-α, IL-2 and INF-γ in patients with HBV recurrence within 1 week before operation and within 3 years after operation were detected. The changes of IL-10, TNF- Results After administration of immunosuppressive agents, the serum concentrations of IL-10, INFγ and TNF-α in HBV-relapsed and non-relapsed patients after liver transplantation were significantly different from those in relapsed patients but not in IL-2 Variety. Conclusion IL-10 and TNF-α can be used as an experimental indicator of HBV recurrence after liver transplantation, with the advantages of noninvasiveness, rapid detection, low cost and easy clinical promotion.