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目的从白色念珠菌本身毒性变化的角度探讨人类免疫缺陷病毒(HIV)感染者易感染口腔念珠菌病的原因。方法通过体外试验从天冬氨酸蛋白酶活性、对颊黏膜上皮细胞的黏附性两方面比较HIV阳性与阴性宿主口腔内白色念珠菌的致病能力。结果在天冬氨酸蛋白酶活性和黏附性方面,HIV阳性口腔念珠菌病致病菌的毒性显著低于HIV阴性口腔念珠菌病致病菌(P<0.01);寄生菌间差异无统计学意义;HIV阳性宿主中,口腔念珠菌病致病菌与寄生菌间差异无统计学意义;而HIV阴性宿主中,口腔念珠菌病致病菌毒性显著高于寄生菌(P<0.01)。结论HIV感染者口腔念珠菌病与某些占主导优势的高毒性菌株无关,而HIV阴性的普通宿主则可能与其选择毒性更强的菌株有关。
Objective To investigate the reason of susceptibility to oral candidiasis in human immunodeficiency virus (HIV) infected patients from the perspective of toxicity of Candida albicans. Methods The virulence of Candida albicans in oral and oral hosts was compared between aspartic protease activity and adhesion to buccal epithelial cells by in vitro experiments. Results The aspartic protease activity and adhesion of HIV - positive oral Candidiasis were significantly lower than that of HIV - negative Candida albicans (P <0.01). There was no significant difference between parasitism In HIV-positive host, there was no significant difference between oral candidiasis and parasitic bacteria. In HIV-negative host, the pathogenicity of oral candidiasis was significantly higher than that of parasites (P <0.01). Conclusion Oral candidiasis is not associated with some dominant strains of high virulence in HIV-infected subjects, while HIV-negative normal hosts may be associated with strains that are more virulent.