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丙戊酸钠属于丙缬草酰胺类药物,是近几年来用于临床抗癫痫的新药。据临床观察治疗效果较好。但尚未见有引起全身大片皮疹乃至全身剥落性皮炎的严重过敏反应报道。患者男性,25岁。于1986年因癫痫病发作收住院。入院时体温、血压正常,心肺功能正常,意识阵阵不清。因患者对苯妥英钠、苯巴比妥治疗极度反感而采用丙戊酸钠治疗,剂量自0.4g/d开始,逐渐增至1.2g/d,以后维持此量治疗。患者情绪稳定,症状缓解,无不适体诉,未见神经、消化、造血、心血管系统及皮肤等方面副反应。在用药后第24d发现患者
Sodium valproate belongs to valproamide and is a new drug used in clinical anti-epilepsy in recent years. According to clinical observation of treatment is better. However, there have been no reports of severe allergic reactions that cause large body rashes and even exfoliative dermatitis. Male patient, 25 years old. In 1986 due to epilepsy onset admitted to hospital. Admission body temperature, normal blood pressure, normal heart and lung function, unconscious bursts of consciousness. Patients treated with phenytoin sodium, phenobarbital extremely objectionable treatment with sodium valproate, the dose starting from 0.4g / d, gradually increased to 1.2g / d, after the maintenance of this amount of treatment. Patients with emotional stability, symptoms, without apnea, no neurological, digestive, hematopoietic, cardiovascular system and skin side effects. The patient was found 24 days after treatment