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采用ApAAp法、ELISA和RIA法检测45例结直肠癌（CRC）患者外周血和局部动静脉血T细胞亚群（CD4+／CD8+）、SIL－2R、TNFα和PGE2，结果发现，局部动静脉血中CDI／CD8+比值随Dukes分期进展而下降；sIL－2R和PGE2浓度则随Dukes分期进展而升高，各期差异显著，局部静脉血PGE2浓度显著高于局部动脉血；TNFα水平也随Dukes分期不同而变化，DukesD期TNFα显著升高；外周CD4+／CD8+比值、PGE2、sIL－2R和TNFα浓度在Dukes不同分期的变化趋势与局部动静脉血相似、结果提示，CRC患者局部及其全身免疫功能紊乱严重程度随Dukes分期进展而逐渐加重，DukesD期患者局部免疫功能受抑最为严重。
The ApAAp method, ELISA and RIA were used to detect peripheral blood and local arteriovenous blood T cell subsets (CD4+/CD8+), SIL-2R, TNFα and PGE2 in 45 patients with colorectal cancer (CRC). The ratio of CDI/CD8+ decreased with the progression of Dukes stage; the levels of sIL-2R and PGE2 increased with the progression of Dukes stage, with significant differences in each period, and the PGE2 concentration in local venous blood was significantly higher than that in local arterial blood; the level of TNFα also changed with the Dukes stage. Different changes, TNFα in Dukes D phase was significantly increased; peripheral CD4+/CD8+ ratio, PGE2, sIL-2R, and TNFα concentrations in different stages of Dukes was similar to local arterial and venous blood, suggesting that local and systemic immune function in CRC patients. The severity of the disorder gradually aggravated with the progression of Dukes’ stage, and the local immunodepression was most severe in Dukes D patients.