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目的:观察鼻咽癌组织中血管内皮因子VEGF和肿瘤抑制基因P16的表达,探讨其与鼻咽癌的预后关系。方法:采用S-P法,检测血管内皮生长因子VEGF和肿瘤抑制基因P16在40例鼻咽癌组织中的表达.分析它们与鼻咽癌患者的复发、转移、生存期之间的相关性。结果:鼻咽癌组织VEGF和肿瘤抑制基因P16的阳性表达率分别为55%和48%,VEGF阳性表达和P16阳性表达与鼻咽癌患者发生转移和较短的生存期有相关性。结论:鼻咽癌组织中VEGF和P16的表达可作为预测鼻咽癌患者的预后因素。
Objective: To observe the expression of vascular endothelial growth factor (VEGF) and tumor suppressor gene P16 in nasopharyngeal carcinoma (NPC) and to explore its relationship with the prognosis of nasopharyngeal carcinoma. Methods: The expressions of vascular endothelial growth factor VEGF and tumor suppressor gene P16 in 40 cases of nasopharyngeal carcinoma were detected by S-P method, and their correlations with the recurrence, metastasis and survival of patients with nasopharyngeal carcinoma were analyzed. Results: The positive rates of VEGF and tumor suppressor gene P16 in nasopharyngeal carcinoma were 55% and 48%, respectively. The positive expression of VEGF and the positive expression of P16 were correlated with the metastasis and short survival of patients with nasopharyngeal carcinoma. Conclusion: The expression of VEGF and P16 in nasopharyngeal carcinoma can be used as a prognostic factor in predicting nasopharyngeal carcinoma.