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目的探讨脑苷肌肽在新生儿缺氧缺血性脑病(HIE)中的治疗效果。方法将HIE患儿随机分成治疗组和对照组。对照组20例给予常规治疗,治疗组22例在常规治疗的基础上给予脑苷肌肽静脉滴注,观察两组临床症状恢复情况和进行新生儿行为神经评分(NBNA)。结果治疗组与对照组总有效率差异有统计学意义(P<0.05)(90.9%vs 75.0%);治疗组临床症状恢复时间均较对照组明显缩短,差异均有统计学意义(P<0.05);治疗组NBNA评分较对照组明显增高,差异亦有统计学意义(P<0.05)。结论脑苷肌肽对新生儿缺氧缺血性脑病有显著疗效。
Objective To investigate the therapeutic effect of cerebroside in neonatal hypoxic-ischemic encephalopathy (HIE). Methods HIE children were randomly divided into treatment group and control group. Twenty patients in the control group were given routine treatment. 22 patients in the treatment group were given intravenous inosine monophosphate intravenously on the basis of routine treatment. The clinical symptoms and the neonatal behavioral neurological score (NBNA) were observed. Results The total effective rate in the treatment group was significantly lower than that in the control group (P <0.05) (90.9% vs 75.0%). The recovery time of the clinical symptoms in the treatment group was significantly shorter than that in the control group (P <0.05) ); The NBNA score of the treatment group was significantly higher than that of the control group, the difference was also statistically significant (P <0.05). Conclusion Cerebroside glycosides have a significant effect on neonatal hypoxic-ischemic encephalopathy.