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胃肠道每日都要接触大量外来抗原,其适应外环境的两个重要机制是发生特异性免疫和非特异性免疫,以排斥穿过上皮的腔内抗原,控制外来抗原引起的全身性免疫反应。调控抗原摄入、免疫反应的发生和生理过程的破坏,则可导致疾病。粘膜免疫反应的异常在许多胃肠疾病中可能具有重要作用。本文讨论了“粘膜屏障”功能,并探讨了粘膜屏障的破坏是如何影响
Gastrointestinal daily exposure to a large number of foreign antigens, its adaptation to the environment two important mechanisms are the occurrence of specific immunity and non-specific immune rejection of intraepithelial antigens through the epithelium to control foreign antigens caused by the systemic immune response . Regulation of antigen intake, the occurrence of immune reactions and the destruction of physiological processes, can lead to disease. Abnormal mucosal immune responses may play an important role in many gastrointestinal diseases. This article discusses the “mucosal barrier” function and explores how mucosal barrier destruction affects