目的　观察左旋精氨酸（ＬＡｒｇｉｎｉｎｅ，ＬＡｒｇ） 对离体兔肺脏保存的保护作用。　方法　３０ 只健康家兔随机分成对照组和左旋精氨酸组（ＬＡｒｇ 组） ，每组１５ 只，对照组兔肺脏给予Ｅｕｒｏｃｏｌｌｉｎｓ 液进行灌注，ＬＡｒｇ 组给予含ＬＡｒｇ的Ｅｕｒｏｃｏｌｌｉｎｓ 液进行灌注，灌注总量６０ｍｌ／ｋｇ ，灌注压力１ ．９６ｋＰａ（２０ｃｍ Ｈ２ Ｏ） ，灌注完毕整取下心肺组织浸入４ ℃保存液中冷藏，７ 小时后取肺进行离体复灌，测定肺血管阻力、血气分析、肺血管对乙酰胆碱舒血管反应性、肺组织湿／ 干重比例及肺组织电子显微镜检查等指标。　结果　对照组肺血管阻力、肺组织湿／ 干重比例均高于ＬＡｒｇ 组（ Ｐ＜ ０ ．０５） ，肺血管对乙酰胆碱反应性对照组较ＬＡｒｇ 组差， 血气分析肺静脉血氧分压对照组下降明显（ Ｐ ＜ ０－０１） ，ＬＡｒｇ 组肺组织形态轻微改变，而对照组肺组织水肿明显、渗出严重。　结论　ＬＡｒｇ具有改善离体兔肺脏的保存效果。 Objective To observe the protective effect of LArginine (LArg) on ​​lung preservation in isolated rabbit. Methods Thirty healthy rabbits were randomly divided into control group and L-arginine group (LArg group), each group of 15 rabbits in the control group were given Eurocollins solution for perfusion in the lungs. LArg group Euro  collins fluid perfusion, perfusion total 60ml / kg, perfusion pressure 1. 96kPa (20cmH 2 O). After perfusion, the whole heart tissue was immersed into 4 ℃ preservation solution and refrigerated. After 7 hours, lungs were taken for reperfusion. Pulmonary vascular resistance, blood gas analysis, pulmonary vascular response to acetylcholine vasoconstriction, Lung wet / dry weight ratio and lung tissue electron microscopy and other indicators. Results The pulmonary vascular resistance and lung wet / dry weight ratio in the control group were higher than those in the LArg group (P <0.05). The pulmonary vascular reactivity to acetylcholine in the control group was lower than that in the LArg group. Pressure control group decreased significantly (P <0-01), L  Arg group lung tissue morphology slightly changed, while the control group of pulmonary edema significantly exudate. Conclusion L  Arg to improve the preservation of isolated rabbit lungs.