1例56岁女性患者因糖尿病周围神经病变给予依帕司他50 mg口服、3次/d。当天服药3次后（首次用药后约10 h），患者面部出现红色丘疹，头颈部出现风团样红斑。服药第2天，皮疹进行性加重并诊断为多形红斑型药疹。考虑为依帕司他所致，将该药换为硫辛酸注射液，并给予地塞米松、维生素C注射液、葡萄糖酸钙注射液对症治疗。3 d后，患者过敏症状减轻，逐步停用抗过敏药物，其他药物继续使用；6 d后，患者无不适，停药出院。20 d后随访，患者皮疹未复发。“,”A 56-year-old female patient received epalrestat 50 mg thrice daily orally because of the diagnosis of diabetic peripheral neuropathy. After 3 times of epalrestat treatment that day (about 10 hours after the first medication), the patient developed red papules on the face and patch-like erythema on the head and neck. On day 2 of epalrestat treatment, the rashes were progressively aggravated and the patient was diagnosed with erythema multiforme-type drug eruption. Considering that it might be caused by epalrestat, the drug was replaced by lipoic acid injection and symptomatic treatments with dexamethasone, vitamin C injection, and calcium gluconate injection were given. Three days later, the patient′s allergic symptoms were alleviated. Anti-allergic drugs were phased out gradually while the other drugs were continued. Six days later, the patient had no discomfort and was discharged from the hospital. At 20 days of follow-up, the rashes did not recur.