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核因子-κB(nuclear factor kappa B,NF-κB)是一种能与多种基因启动子或增强子部位κB位点发生特异性结合并促进其相关基因转录的蛋白质因子,参与调节多种炎症和免疫基因的转录与表达。大量研究表明,其在溃疡性结肠炎(ulcerative colitis,UC)的发生、发展过程中具有重要意义,下面仅就此简要综述如下。
Nuclear factor kappa B (NF-κB) is a protein factor that specifically binds to the κB site of various gene promoters or enhancers and promotes the transcription of its related genes. It is involved in the regulation of various inflammatory diseases And the transcription and expression of immune genes. A large number of studies have shown that it is of great significance in the occurrence and development of ulcerative colitis (UC). The following is a brief summary of the findings.