月经紊乱是皮下埋植剂避孕的主要副反应,多数学者认为埋植后雌激素水平的改变,破坏了子宫内膜组织的维持作用,可导致子宫异常出血。然而,当给予低剂量的雌激素进行对症治疗时,效果并不理想。因此人们推测是否存在其他重要的局部因子参与埋植剂使用者子宫出血的调节。内皮素是近年来发现的最强的血管收缩因子,并且具有促血管平滑肌 Menstrual disorders are the main side effects of subcutaneous implants contraceptives, most scholars believe that the level of estrogen after implantation changes, the destruction of endometrial tissue maintenance, can lead to abnormal uterine bleeding. However, when given low doses of estrogen for symptomatic treatment, the effect is not ideal. Therefore, we speculate whether there are other important local factors involved in the regulation of uterine bleeding in implants users. Endothelin is the most potent vasoconstrictor found in recent years, and has the effects of promoting vascular smooth muscle