新型的非剥脱性点阵激光（non-ablative fractional lasers，NAFL）不同于传统的剥脱激光，前者在保留角质层相对完整的情况下，以点阵排列的形式作用于小部分面积的皮肤，总治疗面积不到治疗区域的10%，保留了大部分正常皮肤，保证组织的快速修复。经FDA批准，非剥脱点阵激光可用于治疗色素沉着、眶周皱纹、皮肤年轻化、痤疮、手术瘢痕和日光性角化等皮肤疾病和皮肤外观改变。除此之外，非剥脱点阵激光也被试用于治疗上述范围以外的疾病，同样取得了较为满意的疗效。本文对非剥脱点阵激光在皮肤科的应用进行综述。“,”The non-ablative fractional lasers are different from conventional ablative lasers,it only tar?get a fraction of skin,leaving up a majority of skin uninvolved.The undamaged tissue, stimulated by the photothermal effects,allow for rapidly epidermal and dermal repairing.Non-ablative fractional la?sers have been approved by the US Food and Drug Administration(FDA)for the treatment of pigment?ed lesions,periorbital rhytides,skin resurfacing,acne and surgical scars, and actinic keratoses.Howev?er,the off-label use to treat other skin disease and abnormal skin conditions is obviously extended.In this review we describe the current clinical use of non-ablative fractional lasers in dermatology.